B – 15 The Role of the Familia: Psychosocial Factors as a Moderator of Cognitive Decline in a Hispanic Child with Epilepsy and GABRA1 Mutation: A Case Study

Abstract Objective Epilepsy is the most common neurological condition in children, affecting 1-2% of US children, with Hispanic children comprising a significant portion. Previous research demonstrates that seizure history and treatment effects contribute to cognitive decline in children with epilepsy (CWE). Psychosocial variables like socioeconomic status, parent education, and access to resources also play a role. However, limited research explores how these factors moderate cognitive decline, especially in Hispanic CWE. This case study presents the neuropsychological profile of an 8-year-old Hispanic male with seizures and GABRA1 mutation, examining the influence of psychosocial factors on cognitive outcomes and addressing a research gap. Method The patient participated in a comprehensive neuropsychological evaluation. The evaluation included standardized measures of intellectual functioning, executive functioning, visual-motor integration, memory, and fine-motor skills. Parent-report measures assessed adaptive functioning, behavior, and executive functioning. Results The patient demonstrated a robust neurocognitive profile, with estimated intellectual functioning in the exceptionally high range (FSIQ=134). High average verbal fluency with high average to average spatial planning, problem-solving abilities, and fine motor speed and dexterity. Working memory, processing speed, and visual-motor integration were average. Parent-report indicated concerns with hyperactivity and attention. Conclusion Cognitive decline in CWE can be multifactorial. Despite the risk of cognitive decline in CWE, the patient in this study demonstrated intact cognitive functioning likely moderated by psychosocial factors, such as high SES, strong family support, and access to resources. These findings suggest that psychosocial variables may serve a protective role in mitigating cognitive decline in CWE, particularly in Hispanic populations.