Isolation and Structure Elucidation of Uric Acid Lowering Lipopeptides from an <i>Okeania</i> sp. Marine Cyanobacterium
Two linear lipopeptides mabuniamide B (<b>1</b>) and C (<b>2</b>) were isolated from an <i>Okeania</i> sp. marine cyanobacterium collected from the coast of Okinawa. Their structures were elucidated by spectroscopic analyses, and their absolute configurations of amino acid residues were determined using Marfey's analysis of the hydrolysates of <b>1</b> and <b>2</b>. In addition, <b>1</b> and <b>2</b> inhibited uric acid production in cultured AML12 cells.
Authors
- Kiyotake Suenaga (ORCID: https://orcid.org/0000-0001-5343-5890)
- Naoaki Kurisawa (ORCID: https://orcid.org/0000-0002-3204-7693)
- Noriyuki Natsume
- Toshiaki Teruya (ORCID: https://orcid.org/0000-0002-7018-7734)
- S. Higa
- Kazumasa Yagisawa
Institutions
- Keio University (JP)
- University of the Ryukyus (JP)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c01074
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81