Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome
Higher baseline white matter hyperintensity (WMH) volume and plasma glial fibrillary acidic protein (GFAP) concentration were associated with a higher likelihood of progressing from cognitively stable to either mild cognitive impairment or clinical Alzheimer's disease in Down syndrome. WMH volume and GFAP concentration discriminated between those who progressed and those who did not. Models including the independent and interactive effects of WMH and GFAP more accurately discriminated between participants who progressed diagnostically from those who did not. Individuals with evidence of amyloid pathology were more likely to progress if they also had elevated WMH or GFAP.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Natalie C. Edwards (ORCID: https://orcid.org/0000-0002-8501-1467)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Sabrina Simoes (ORCID: https://orcid.org/0000-0002-9976-2501)
- Batool M. Rizvi (ORCID: https://orcid.org/0000-0001-9120-3943)
- Joseph Hyungwoo Lee (ORCID: https://orcid.org/0000-0002-2000-4821)
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Shahid Zaman (ORCID: https://orcid.org/0000-0003-1639-6014)
- H. Diana Rosas (ORCID: https://orcid.org/0000-0001-9360-7511)
- Sid E. O’Bryant (ORCID: https://orcid.org/0000-0003-0582-5266)
- José Gutierrez (ORCID: https://orcid.org/0000-0002-2175-8078)
- Mohamad J. Alshikho
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Mark E. Mapstone (ORCID: https://orcid.org/0000-0003-0280-8057)
- Michael A. Yassa (ORCID: https://orcid.org/0000-0002-8635-1498)
- Ira T. Lott (ORCID: https://orcid.org/0000-0002-3107-0752)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- Melissa Petersen (ORCID: https://orcid.org/0000-0002-6543-1819)
- Lisi Flores Aguilar (ORCID: https://orcid.org/0000-0002-7962-7433)
- Shorena Janelidze
- Olivia M. Ericsson
Institutions
- University of North Texas (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of North Texas Health Science Center (US)
- University of Pittsburgh (US)
- Lund University (SE)
- University of California, Irvine (US)
- University of Cambridge (GB)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Skåne University Hospital (SE)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1002/alz.70726
- Citations
- 2
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- National Institutes of Health
- NIHR Cambridge Biomedical Research Centre
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development