Discordance Between p16-Expression and HPV-Status in Sinonasal Carcinoma: A Multicenter Retrospective Study
Our findings underscore the limitations of p16 as a single surrogate marker for detecting HPV-associated sinonasal cancer. Future research on the role of HPV in sinonasal cancer should integrate complementary testing methods (like p16Ink4A immunohistochemistry and HPV DNA/mRNA analysis) and aim for test standardization.
Authors
- Nina Wenda (ORCID: https://orcid.org/0000-0003-4002-9257)
- Christian Stephan Betz (ORCID: https://orcid.org/0000-0003-3188-1026)
- Leoni Ramke
- Jan Gosepath (ORCID: https://orcid.org/0000-0002-4319-1631)
- Marta Barde
- Sebastian Wagner (ORCID: https://orcid.org/0000-0001-5603-3897)
- Till Sebastian Clauditz (ORCID: https://orcid.org/0000-0002-4257-856X)
- Anna Sophie Hoffmann (ORCID: https://orcid.org/0009-0002-6400-5604)
- Henrike Zech (ORCID: https://orcid.org/0000-0002-3514-1976)
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3390/cancers17193135
- Citations
- 2
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 4.01