Expedient Route to Access C8-Carbonylated Quinolines via Photo-Induced C(sp3)–H Oxidation
Abstract Visible light-enabled C(sp3)–H oxidation of 8-alkylquinolines has been accomplished utilizing [Mes-Acr-Me]BF4 under air. The reaction offers an effective synthetic approach to direct access of C8-carbonyl quinolines bearing aldehydes, ketones, and esters groups and allows other important functional handles through postsynthetic modification. The site-selective C(sp3)–H oxidation, use of air as oxidant, substrate scope, and postsynthetic potential are the salient practical features.
Authors
- Bijoy Debnath (ORCID: https://orcid.org/0000-0003-0838-4515)
- Tharmalingam Punniyamurthy (ORCID: https://orcid.org/0000-0003-4696-8896)
- Santu Mandal (ORCID: https://orcid.org/0009-0000-7931-5918)
- S. K. Bera (ORCID: https://orcid.org/0000-0003-1140-6762)
- Pallabi Paul (ORCID: https://orcid.org/0009-0009-8533-4969)
Institutions
- Indian Institute of Technology Guwahati (IN)
Publication Details
- Journal
- Synthesis
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1055/a-2708-6984
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00