N-formyl methionine mediates NETosis of neutrophil to promote sepsis-induced cardiomyopathy via the FPR1 pathway
These data reveal the role of fMet-mediated FPR1/HIF-1α activation in promoting SIC through the NETosis, indicating novel therapeutic strategy for SIC.
Authors
- Junjie Xiang
- Xiaohong Yu (ORCID: https://orcid.org/0000-0003-2352-2023)
- Hui Lin (ORCID: https://orcid.org/0000-0001-5459-800X)
- Lili Xu (ORCID: https://orcid.org/0000-0001-6724-6257)
- Yun Wang (ORCID: https://orcid.org/0000-0002-1475-7413)
- Gang Ye (ORCID: https://orcid.org/0000-0003-1266-0762)
- Sen Chen (ORCID: https://orcid.org/0000-0002-9579-8080)
- Yue Shan (ORCID: https://orcid.org/0000-0001-5707-4375)
- Haodi Gu
Institutions
- Hubei University of Medicine (CN)
- Shaoxing University (CN)
- Wenzhou Medical University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Beijing Friendship Hospital (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.intimp.2025.115602
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00