Resistance and chemosensitivity restoration in human cytomegalovirus-infected tumor cells to doxorubicin through combined treatment with aqueous fullerene dC<sub>60</sub>
Human cytomegalovirus infection induces doxorubicin resistance in both hematopoietic (promyelocytic leukemia, monocytic leukemia) and solid (hepatocellular carcinoma) tumor models. Importantly, combined treatment doxorubicin with aqueous fullerene dC<sub>60</sub> not only overcomes virus-mediated drug resistance in monocytic leukemia cells but also enhances cytotoxicity at reduced doxorubicin concentrations, offering prospects for developing less toxic combined therapeutic regimens.
Authors
- Ruslan A. Simonov (ORCID: https://orcid.org/0000-0002-7706-8228)
- Т. В. Гребенникова (ORCID: https://orcid.org/0000-0002-6141-9361)
- Sergey Andreev (ORCID: https://orcid.org/0000-0001-8297-579X)
- Ekaterina I. Lesnova (ORCID: https://orcid.org/0000-0002-2801-6843)
- Yana Yu. Chernoryzh (ORCID: https://orcid.org/0000-0001-9848-8515)
- Kushch Aa (ORCID: https://orcid.org/0000-0002-3396-5533)
- Fedorova Ne (ORCID: https://orcid.org/0000-0001-8466-7993)
- Kirill I. Yurlov (ORCID: https://orcid.org/0000-0002-4694-2445)
Institutions
- Gamalei Institute of Epidemiology and Microbiology (RU)
- Ministry of Health of the Russian Federation (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Problems of Virology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.36233/05074088300
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00