Time‐Series Transcriptomics Identifies Xanthine Dehydrogenase in Injured Neurons Correlated With Orthodontic Pain
Xdh is highly expressed in Atf3+ injured neurons during OTM pain, likely intensifying nociceptive signals through oxidative and inflammatory pathways. These findings highlight Xdh as a promising therapeutic target for alleviating orthodontic pain while preserving effective tooth movement.
Authors
- Wenli Lai (ORCID: https://orcid.org/0000-0002-7652-739X)
- Xing Lu (ORCID: https://orcid.org/0000-0002-2501-2927)
- Minqi Li (ORCID: https://orcid.org/0000-0001-9980-1382)
- Hu Long (ORCID: https://orcid.org/0000-0002-6020-6559)
- Xiaoqian Zhang (ORCID: https://orcid.org/0000-0003-4056-0080)
- Xiaoqi Zhang (ORCID: https://orcid.org/0000-0003-0707-0928)
- Qingxuan Wang (ORCID: https://orcid.org/0000-0003-2306-4341)
- Waseem Ai-Gumaei
Institutions
- Shandong University (CN)
- Sichuan University (CN)
- Kunming Medical University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Orthodontics and Craniofacial Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1111/ocr.70036
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33