Comparative evaluation of disc diffusion and broth microdilution methods for aztreonam/avibactam susceptibility testing in Enterobacterales
Aztreonam/avibactam showed potent in vitro activity against MBL- and KPC-producing Enterobacterales. Using the 2025 EUCAST breakpoint, all isolates in the ATU tested susceptible by BMD, leading to high MEs of the DD method. A 22 mm breakpoint would have corrected this discrepancy in our cohort.
Authors
- S. Vourli
- James Hatcher (ORCID: https://orcid.org/0000-0003-2417-346X)
- Athanasios Tsakris (ORCID: https://orcid.org/0000-0003-0656-4715)
- Louis Grandjean (ORCID: https://orcid.org/0000-0002-1457-8327)
- Georgia Vrioni
- Ioannis Baltas (ORCID: https://orcid.org/0000-0002-8008-4835)
- Ioannis Skiadas (ORCID: https://orcid.org/0000-0002-6458-678X)
- Vassilios Grammelis
- H.G. Solanki
- Damianos Menegas
- Nikoletta Smyrni
- Deny Tsakri (ORCID: https://orcid.org/0009-0003-1978-5864)
- Evelyn Murrell
- Eftychia Kiousi
- Zacharias Tsakris
- Gabriella Kuczmar
Institutions
- Pfizer (United Kingdom) (GB)
- National and Kapodistrian University of Athens (GR)
- National Centre of Scientific Research "Demokritos" (GR)
- Great Ormond Street Hospital (GB)
- Institute of Child Health (IN)
- Institute of Biosciences & Applications
- University College London (GB)
- Hella (Germany) (DE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1093/jac/dkaf361
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59