Analysis of the Radiosensitivity Index in Paired Preneoadjuvant and Postneoadjuvant Therapy Triple-Negative Breast Cancer
Pretreatment RSI cluster identity is associated with the degree of immune enrichment and response to NAST in TNBC. Initially immune-enriched TNBCs that do not achieve a pCR to NAST exhibit a decrease in predicted radiosensitivity compared with paired pretreatment tumors.
Authors
- Lauren Nye (ORCID: https://orcid.org/0000-0001-6921-0987)
- Harsh B. Pathak (ORCID: https://orcid.org/0000-0003-4034-0520)
- Anne O’Dea
- Rashna Madan
- Qamar J. Khan (ORCID: https://orcid.org/0000-0002-6287-020X)
- Andrew K. Godwin (ORCID: https://orcid.org/0000-0002-3987-9580)
- Rachel Yoder (ORCID: https://orcid.org/0009-0008-6800-1743)
- Julia R. White (ORCID: https://orcid.org/0000-0001-6624-5631)
- Joshua M. Staley (ORCID: https://orcid.org/0000-0001-9273-0286)
- Priyanka Sharma (ORCID: https://orcid.org/0000-0001-8592-2239)
- Gregory Crane
- Bruce F. Kimler (ORCID: https://orcid.org/0000-0001-7021-6964)
- Joyce O’Shaughnessy (ORCID: https://orcid.org/0000-0001-6764-2807)
- Shane Richard Stecklein (ORCID: https://orcid.org/0000-0001-8322-5886)
- Deepti Satelli
- Maura O’Neil (ORCID: https://orcid.org/0000-0001-9740-1027)
- Roberto Salgado
Institutions
- Texas Oncology (US)
- Peter MacCallum Cancer Centre (AU)
- The University of Kansas Cancer Center (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.09.038
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94