Invasive mole presenting as abnormal uterine bleeding: a case report and review of literature

Invasive mole is a type of gestational trophoblastic neoplasia (GTN). It usually occurs after a molar or non-molar pregnancy. Here we would like to present a 47-year-old nulligravida lady who does not give any history of antecedent pregnancy. She had symptoms of abnormal uterine bleeding (AUB) and came to the causality with heavy flow. Beta hCG was very high and MRI showed uterine tumor. She underwent total abdominal hysterectomy with bilateral salpingoopherectomy which showed invasive mole FIGO stage II. Her WHO prognostic score was 9 and hence she received EMA-CO regimen of chemotherapy. GTN can present in different ways, even without a history of previous pregnancy. In such situations a high level of suspicion and a simple Beta hCG level can clinch the diagnosis.

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Publication Details

Journal
International Journal of Reproduction Contraception Obstetrics and Gynecology
Published
2025-09-26
DOI
https://doi.org/10.18203/2320-1770.ijrcog20253115
Primary Topic
Gestational Trophoblastic Disease Studies
Type
article
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article

Invasive mole presenting as abnormal uterine bleeding: a case report and review of literature

Neetha Nandan, Vijith Shetty, Rachana Lekkala
International Journal of Reproduction Contraception Obstetrics and Gynecology
Gestational Trophoblastic Disease Studies
article

Invasive mole presenting as abnormal uterine bleeding: a case report and review of literature

Neetha Nandan, Vijith Shetty, Rachana Lekkala
article en

Abstract

Invasive mole is a type of gestational trophoblastic neoplasia (GTN). It usually occurs after a molar or non-molar pregnancy. Here we would like to present a 47-year-old nulligravida lady who does not give any history of antecedent pregnancy. She had symptoms of abnormal uterine bleeding (AUB) and came to the causality with heavy flow. Beta hCG was very high and MRI showed uterine tumor. She underwent total abdominal hysterectomy with bilateral salpingoopherectomy which showed invasive mole FIGO stage II. Her WHO prognostic score was 9 and hence she received EMA-CO regimen of chemotherapy. GTN can present in different ways, even without a history of previous pregnancy. In such situations a high level of suspicion and a simple Beta hCG level can clinch the diagnosis.

International Journal of Reproduction Contraception Obstetrics and GynecologyVol. 14(10)
K S Hegde Medical Academy (IN)
Openalex Percentile: Top 64%
Gestational Trophoblastic Disease Studies
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Invasive mole presenting as abnormal uterine bleeding: a case report and review of literature — Neetha Nandan, Vijith Shetty, et al. · International Journal of Reproduction Contraception Obstetrics and Gynecology (2025) | TGRS Research Map | TGRS