N-type Ca2+ channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum
The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.
Authors
- Kostas Vekrellis (ORCID: https://orcid.org/0000-0001-5702-9953)
- Εμμανουέλα Λεάνδρου (ORCID: https://orcid.org/0000-0001-7364-0445)
- Evangelia Emmanouilidou (ORCID: https://orcid.org/0000-0003-3106-8270)
- Ioanna Chalatsa
Institutions
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- Biomedical Research Foundation of the Academy of Athens (GR)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1038/s41531-025-01110-z
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hellenic Foundation for Research and Innovation