Prevalence of MUTYH Monoallelic Variants in Patients With Hereditary Cancer Using Multigene Panel Testing
The higher MUTYH mutation rate observed in the cancer cohort compared with the control group; cancer recurrence observed in the heterozygous carriers and in both maternal and paternal family branches of patients harboring a DM suggests that MUTYH PVs may play a role in cancer predisposition and progression, even when monoallelic.
Authors
- Luana Passariello
- Chiara Della Pepa
- Anna Maria Molinari (ORCID: https://orcid.org/0000-0002-6503-432X)
- Liuska Pesce (ORCID: https://orcid.org/0000-0002-8753-8166)
- Gemma Caliendo
- Luisa Albanese
- Maria Teresa Vietri (ORCID: https://orcid.org/0000-0001-7849-9970)
- Anna Cozzolino
- Alessia Mignano
- Francesca Iengo
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Centro Medicina della Riproduzione (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1002/cam4.71231
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00