The Efficacy of Umbilical Cord (UC) Serum, Human Platelet Lysate, and the Synergistic Effect of Nano-curcumin and Crocin as Supplements in theProliferation and Survival of Human UC-derived Mesenchymal Stromal Cells (MSCs)
UCS and HPL are robust, ethically sound replacements for FBS in MSC biomanufacturing. Crocin can further enhance culture outcomes by improving cell survival and maintaining stem cell properties. These findings support the development of optimized, xeno-free culture systems for scalable MSC production, which is crucial for advancing regenerative medicine therapies.
Authors
- Akram Sheikh
- Javad Baharara (ORCID: https://orcid.org/0000-0001-9728-2945)
- Mohammad Amin Kerachian (ORCID: https://orcid.org/0000-0001-5016-2882)
- Najmeh Kaffash Farkhad (ORCID: https://orcid.org/0000-0002-5044-8538)
- Mahmoud Reza Jafari
- Jalil Tavakol Afshari
Institutions
- Mashhad University of Medical Sciences (IR)
- Islamic Azad University, Mashhad (IR)
Publication Details
- Journal
- Current Stem Cell Research & Therapy
- Published
- 2025-09-24
- DOI
- https://doi.org/10.2174/011574888x372692250918112149
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00