Endometriosis-associated infertility alters the microRNA signatures of cumulus cells with a particularly pronounced effect in oocytes that failed fertilization
This study identified for the first time an altered miRNA signature in CCs of E patients, pointing towards compromised oocyte competence. Besides, in E patients, a characteristic CCs miRNA footprint for oocytes that can be successfully fertilized despite the disease has been revealed. The study charts new territory for non-invasive diagnosis and personalized treatments based on miRNAs to improve oocyte competence in E patients under ART treatments.
Authors
- C. Almiñana (ORCID: https://orcid.org/0000-0003-0495-7099)
- Stefan Bauersachs (ORCID: https://orcid.org/0000-0003-2450-1216)
- Susanne E. Ulbrich (ORCID: https://orcid.org/0000-0003-0355-3869)
- Marianne R. Spalinger (ORCID: https://orcid.org/0000-0003-4498-0058)
- Mara D. Saenz-de-Juano (ORCID: https://orcid.org/0000-0002-2860-2252)
- Brigitte Leeners (ORCID: https://orcid.org/0000-0003-4027-6151)
- Sofia Makieva (ORCID: https://orcid.org/0000-0001-6143-3553)
- A. M. Velasco (ORCID: https://orcid.org/0000-0003-3469-8884)
- Nicole Berenice Narváez Cervantes (ORCID: https://orcid.org/0000-0002-1489-3431)
- Min Xie (ORCID: https://orcid.org/0000-0001-9079-1712)
Institutions
- University of Zurich (CH)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Biological Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s40659-025-00641-2
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universität Zürich
- EMDO Stiftung
- Functional Genomics Center Zurich