Inflammation-mediated regional brain alterations associated with mild cognitive impairment in knee osteoarthritis
Our findings suggest that IL-6-driven mPFC dysfunction is a potential pathway linking KOA-related inflammation to MCI, while highlighting the combined utility of ReHo/ALFF metrics in mPFC, precuneus, and temporal regions as potential neuroimaging biomarkers. This multimodal approach advances understanding of neuroinflammatory mechanisms in osteoarthritis and provides a framework for early detection of cognitive vulnerability in KOA populations.
Authors
- Congqiang Hao (ORCID: https://orcid.org/0009-0005-1354-3367)
- Kechong Zhou (ORCID: https://orcid.org/0000-0002-7805-1575)
- Quan Sun (ORCID: https://orcid.org/0000-0001-8324-2803)
- Chao Li (ORCID: https://orcid.org/0000-0002-2445-7545)
- Peng Zhang (ORCID: https://orcid.org/0000-0003-1777-3790)
- Zhengxi Li (ORCID: https://orcid.org/0000-0003-4638-8971)
Institutions
- Hubei University of Arts and Science (CN)
- Tianjin People's Hospital (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13075-025-03646-0
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00