COA6 deficiency inhibits hepatocellular carcinoma progression by regulating cuproptosis through the JAK/STAT signaling pathway
In conclusion, our data show that COA6 was highly expressed in HCC, and silencing COA6 blocked the JAK-STAT signaling pathway and activated cuproptosis, and inhibits the malignant phenotype and tumor growth of HCC cells. Therefore, targeting COA6 may be a potential therapeutic approach to inhibit HCC progression.
Authors
- Yujie Zhou (ORCID: https://orcid.org/0000-0002-6740-9818)
- Haonan Sun (ORCID: https://orcid.org/0000-0002-7334-9604)
- Xiaoming Wei
- Yang Yang (ORCID: https://orcid.org/0000-0001-7845-5660)
- Lixin Zhu
- Ke Tian (ORCID: https://orcid.org/0009-0002-2488-371X)
- Xiaohang Niu (ORCID: https://orcid.org/0009-0008-9711-3701)
- Mingjin Zhang (ORCID: https://orcid.org/0000-0002-1653-108X)
- Fubao Liu (ORCID: https://orcid.org/0009-0003-2874-2751)
- Mingya Yang (ORCID: https://orcid.org/0000-0002-6459-494X)
Institutions
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.bbamcr.2025.120065
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00