Anti-P antibodies that impair memory perturb hippocampal glutamatergic receptor trafficking, synapse structure and microglia
Anti-P antibodies acutely impair glutamatergic receptor recycling and surface expression, while their long-term effects lead to sustained memory impairment associated with altered neuronal and microglial architecture, and PTPMEG increased levels preceding PSD protein loss. These findings provide mechanistic insight into anti-P-mediated cognitive dysfunction and may inform therapeutic strategies for neuropsychiatric SLE.
Authors
- Mariana Labarca (ORCID: https://orcid.org/0000-0001-6455-3569)
- Marcela Bravo‐Zehnder
- M Ricca (ORCID: https://orcid.org/0000-0002-6168-574X)
- Alejandra Catenaccio (ORCID: https://orcid.org/0000-0002-2724-211X)
- Bernardita Medel (ORCID: https://orcid.org/0009-0006-9849-4214)
- Daniela Cortés-Díaz
- Francisca Barake (ORCID: https://orcid.org/0000-0003-4528-7415)
- Sebastián Espinoza (ORCID: https://orcid.org/0000-0003-3168-6802)
- Alfonso González (ORCID: https://orcid.org/0000-0002-6139-4299)
- Cristian Herrera-Cid (ORCID: https://orcid.org/0000-0002-2010-4785)
- Jaime Venegas (ORCID: https://orcid.org/0000-0002-8583-5079)
- Cláudio Retamal (ORCID: https://orcid.org/0000-0001-8618-2260)
- Manuel Varas‐Godoy (ORCID: https://orcid.org/0000-0001-5857-4793)
- Bredford Kerr (ORCID: https://orcid.org/0000-0001-8714-8726)
- Adely de la Peña (ORCID: https://orcid.org/0000-0002-2588-3925)
- Fanny Guzmán (ORCID: https://orcid.org/0000-0002-7829-0568)
- Francisca Pérez-Molina
- Cheril Tapia‐Rojas (ORCID: https://orcid.org/0000-0002-7084-0318)
- Loreto Massardo (ORCID: https://orcid.org/0000-0001-5678-560X)
- Ángela Campos (ORCID: https://orcid.org/0000-0002-4404-5783)
- Claudia Jara
- Nicole Díaz-Valdivia
Institutions
- Universidad Mayor (CL)
- University of Copenhagen (DK)
- Inserm (FR)
- San Sebastián University (CL)
- Fundación Ciencia and Vida (CL)
- Pontificial Catholic University of Valparaiso (CL)
- Institute of Normal and Pathological Physiology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s10020-025-01339-7
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Agencia Nacional de Investigación y Desarrollo