[11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics
[<sup>11</sup>C]HSP990 is a promising tracer for identifying Hsp90-overexpressing tumours and may hold potential for patient stratification, prognosis, and therapy monitoring of novel Hsp90 therapeutics. High healthy brain uptake of this tracer precluded the differentiation of the tumour in the intracranial NS/CT-2A tumour model, therefore [<sup>11</sup>C]HSP990 might not be a suitable tracer for the glioblastoma imaging. Tracer with a longer half-life might be needed to compare the washout of the tracer from the brain and the tumour tissue over several hours to identify a suitable imaging window.
Authors
- Koen Vermeulen (ORCID: https://orcid.org/0000-0003-2048-6530)
- Frédéric Rousseau (ORCID: https://orcid.org/0000-0002-9189-7399)
- Joost Schymkowitz (ORCID: https://orcid.org/0000-0003-2020-0168)
- Valeria Narykina
- Frederik De Smet (ORCID: https://orcid.org/0000-0002-6669-3335)
- Romy Cools (ORCID: https://orcid.org/0000-0002-6883-4031)
- Marleen Derweduwe (ORCID: https://orcid.org/0000-0002-4960-4847)
- Brian S. J. Blagg (ORCID: https://orcid.org/0000-0002-6200-3480)
- Mattéo Riva (ORCID: https://orcid.org/0000-0001-5962-5513)
- An Coosemans (ORCID: https://orcid.org/0000-0002-7321-4339)
- Guy Bormans (ORCID: https://orcid.org/0000-0002-0335-7190)
- Aaron Ziani-Zeryouh
- Sanket J. Mishra (ORCID: https://orcid.org/0000-0002-6010-7374)
Institutions
- University of Notre Dame (US)
- University of Kansas (US)
- Rega Institute for Medical Research (BE)
- VIB-KU Leuven Center for Cancer Biology (BE)
- CHU Dinant Godinne UCL Namur (BE)
- Belgian Nuclear Research Centre (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- UCLouvain (BE)
- KU Leuven (BE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s41181-025-00386-z
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- National Institutes of Health