Ultrasound Measurements of Testicular Size After Exposure to Cisplatin Chemotherapy in Adult Male Rats

Ultrasound has been used to diagnose many diseases in human and veterinary medicine, with excellent results. The present study aimed to assess the effect of cisplatin on testicular size using ultrasound imaging. The study was conducted on adult male rats divided into two equal groups: a control group (C) and an experimental group (CP) which received an intraperitoneal injection (I.P.) of 5 mg/kg cisplatin once a week for two consecutive weeks on day 6 (d6) and d12 of the experiment. After a period of 3 days following each injection, an ultrasound scan was performed to measure testicular volume following exposure to cisplatin (CP). The results indicate that testicular size increased significantly after the first dose (d6) (L: 1.67 ± 0.09, W: 0.91 ± 0.10) compared with the control group (L: 1.53 ± 0.07, W: 0.92 ± 0.03) and continued to increase after the second dose (d12) (L: 1.96 ± 0.18, W: 0.98 ± 0.11). In conclusion, these results indicate that the use of ultrasound technology to monitor testicular size after each dose produced excellent and very clear results, enabling testicular lesions to be diagnosed after cisplatin chemotherapy without the need for surgery or dissection.