Establishment and validation of a recurrent prediction model for glioma: extrinsic apoptotic molecules FADD and CASP8 are closely associated with glioma recurrence

Our study successfully developed a predictive model based on 9 recurrence-related genes, enabling accurate stratification of glioma patients into high- and low-risk recurrence groups. Furthermore, we identified apoptosis, particularly the extrinsic apoptotic pathway involving FADD and CASP8, as a critical mechanism associated with glioma recurrence. These findings provide valuable insights into the molecular basis of glioma recurrence and may facilitate the development of targeted therapeutic strategies.