Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellum
Our results reveal the essential functions of cohesin in gene transcription by regulating genome folding across multiple length scales in cerebellar granule neurons. Its roles in orchestrating both local and compartment-level genomic interactions highlight the additional layers of regulation for genes selectively expressed in mature post-mitotic neurons in vivo.
Authors
- Ziyu Zhao
- Omar A. Payán Parra (ORCID: https://orcid.org/0000-0002-0005-8355)
- Tomoko Yamada
- Yue Yang (ORCID: https://orcid.org/0000-0003-0785-591X)
Institutions
- Northwestern University (US)
- Northwestern University (PH)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13072-025-00625-2
- Citations
- 1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Northwestern University
- National Institutes of Health