Analysis of spermidine’s effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS
The findings suggest that reduced spermidine levels may be a significant risk factor for CHD. This study supports the potential of spermidine as a biomarker for CHD risk assessment and its development as a therapeutic target. The integration of genetic and biochemical methodologies enhances our understanding of the role of spermidine in cardiovascular health and its utility in managing CHD risk.
Authors
- Yaodong Ding (ORCID: https://orcid.org/0000-0002-5388-2321)
- Yuncong Shi
- Yong Zeng (ORCID: https://orcid.org/0000-0001-6962-0046)
- Ren Feng (ORCID: https://orcid.org/0000-0002-7352-8127)
- Yang Zhang (ORCID: https://orcid.org/0000-0003-1718-0733)
- Na Li (ORCID: https://orcid.org/0000-0002-0789-0515)
- Tianyi Wang (ORCID: https://orcid.org/0000-0002-7923-3717)
- Zhenhua Zhao (ORCID: https://orcid.org/0000-0003-2330-4288)
- Zhennan Li (ORCID: https://orcid.org/0009-0008-5886-1651)
- Yongping Bai (ORCID: https://orcid.org/0000-0002-7316-6066)
- Li Lin (ORCID: https://orcid.org/0009-0005-6010-4586)
Institutions
- Beijing Anzhen Hospital (CN)
- MemorialCare Health System (US)
Publication Details
- Journal
- Hereditas
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s41065-025-00568-4
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China