Cellular and proteomic differences associated with lithium response in olfactory neuroepithelium cells of bipolar disorder patients
This study underscores cellular and proteomic differences between BDNR and BDR cells, with lithium exerting pronounced effects on BDR cells while having limited impact on BDNR cells. These findings advance our understanding of lithium responsiveness in BD and point to potential biomarkers and therapeutic targets for personalized treatment approaches.
Authors
- Cristina Romero-López-Alberca (ORCID: https://orcid.org/0000-0001-5856-8668)
- Clara García-Mompó (ORCID: https://orcid.org/0000-0002-1043-8415)
- Jose I. Pérez‐Revuelta (ORCID: https://orcid.org/0000-0003-0451-4909)
- Jose Ma Villagrán Moreno
- Alejandra Delgado-Sequera (ORCID: https://orcid.org/0000-0003-0675-413X)
- María Hidalgo‐Figueroa (ORCID: https://orcid.org/0000-0001-5241-0931)
- Ma Carmen Durán-Ruiz (ORCID: https://orcid.org/0000-0003-3954-3734)
- Esther Berrocoso (ORCID: https://orcid.org/0000-0003-0208-7472)
- Anaid Pérez‐Ramos (ORCID: https://orcid.org/0000-0001-6515-2425)
- Ingrid Marquez-Estefenn
Institutions
- Instituto de Salud Carlos III (ES)
- Universidad de Cádiz (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Biomedical Research and Innovation Institute of Cadiz (ES)
- Hospital Universitario Puerta del Mar (ES)
- Hospital Jerez Puerta del Sur (ES)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s10020-025-01343-x
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Málaga
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red de Salud Mental
- Junta de Andalucía
- Instituto de Salud Carlos III