Autophagic impairment in sleep–wake circuitry is linked to sleep loss at the early stages of Alzheimer’s disease

These findings demonstrate the vulnerability of sleep-regulating neurons to proteostatic dysfunction and the sleep-autophagy linkage as an early, and treatable, Alzheimer's disease mechanism.

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Publication Details

Journal
Molecular Neurodegeneration
Published
2025-09-26
DOI
https://doi.org/10.1186/s13024-025-00877-2
Citations
1
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
1.43
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article

Autophagic impairment in sleep–wake circuitry is linked to sleep loss at the early stages of Alzheimer’s disease

Christopher D. Morrone, Wai Haung Yu, Arielle A. Tsang
1 citations
Molecular Neurodegeneration
Sleep and Wakefulness Research
1.43
article

Autophagic impairment in sleep–wake circuitry is linked to sleep loss at the early stages of Alzheimer’s disease

Christopher D. Morrone, Wai Haung Yu, Arielle A. Tsang
article en
1 citations

Abstract

These findings demonstrate the vulnerability of sleep-regulating neurons to proteostatic dysfunction and the sleep-autophagy linkage as an early, and treatable, Alzheimer's disease mechanism.

Molecular NeurodegenerationVol. 20(1)
Centre for Addiction and Mental Health (CA), University of Toronto (CA), Scarborough Health Network (CA)
Openalex Percentile: Top 15%
Sleep and Wakefulness Research
1.43
DOIOpen Access PDFOpenAlex
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