Mesenchymal stem cells undergoing apoptosis recover cyclophosphamide-induced cleft palate through modulation of NLR signaling mediated pyroptosis
Our studies revealed exogenous MSC underwent apoptosis and released apoVs to repair fetal cleft palate defects, which mechanistically reduced the NLR signaling mediated pyroptosis in palatal shelves.
Authors
- Hongbin Lü (ORCID: https://orcid.org/0000-0001-7749-3593)
- Peiyuan Zhang (ORCID: https://orcid.org/0000-0002-6737-4109)
- Xuefeng Hu
- Lizhen Lan (ORCID: https://orcid.org/0009-0002-1121-3485)
- Xi Zheng (ORCID: https://orcid.org/0009-0001-7278-2553)
- Xiaohan Geng
- Bingdong Sui
- Yu Fu (ORCID: https://orcid.org/0000-0003-1976-664X)
Institutions
- Fujian Normal University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13287-025-04652-4
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China