NPC1 as a novel therapeutic target for induction of pyroptosis in cancers
This study reveals that NPC1 may be a potential therapeutic target for the treatment of human cancers.
Authors
- Wei Wu (ORCID: https://orcid.org/0000-0001-5643-8739)
- Rui Duan (ORCID: https://orcid.org/0000-0002-0187-9331)
- Chuanchao Zhang (ORCID: https://orcid.org/0000-0003-0690-613X)
- Liuling Xiao (ORCID: https://orcid.org/0000-0002-3013-4523)
- Youli Zu (ORCID: https://orcid.org/0000-0001-8574-9974)
- Qiang Wang (ORCID: https://orcid.org/0000-0001-5095-4062)
- Yu-Fei Zhang
- Pan Su (ORCID: https://orcid.org/0000-0002-7133-1777)
- Qing Yi
- Ling Zhong (ORCID: https://orcid.org/0009-0008-1825-7273)
- Jianfei Qian (ORCID: https://orcid.org/0000-0003-4763-4409)
- Qi Guo
Institutions
- Houston Methodist (US)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s40364-025-00823-w
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Houston Methodist Hospital
- University of Texas MD Anderson Cancer Center
- Houston Methodist Research Institute
- National Cancer Institute