An enteropathogenic microbial toxin modulates the breast cancer epigenome resulting in concurrent silencing of tumor suppressor genes
Collectively, BFT exposure epigenetically modifies the expression of TSGs and impacts migration/invasion potential of breast cancer cells, and treatment with demethylation agent(s) and HDAC inhibitors effectively diminishes the functional impact of BFT.
Authors
- Abhishek Saxena (ORCID: https://orcid.org/0000-0003-0595-2118)
- Dipali Sharma (ORCID: https://orcid.org/0000-0002-5032-974X)
- Deeptashree Nandi (ORCID: https://orcid.org/0000-0001-8363-9659)
- Deepak Verma (ORCID: https://orcid.org/0000-0003-4699-9609)
- Sheetal Parida (ORCID: https://orcid.org/0000-0002-2526-987X)
Institutions
- Johns Hopkins University (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13058-025-02111-9
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61