IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function
IRS2 plays a key role in OA pathogenesis and targeting it may provide a promising therapeutic approach for OA.
Authors
- Guoyou Zou (ORCID: https://orcid.org/0000-0002-9099-6168)
- Yaohui Yu
- Hao Zhu (ORCID: https://orcid.org/0000-0002-8417-9698)
- Chaoren Qin (ORCID: https://orcid.org/0000-0001-6646-237X)
- Kai Chen (ORCID: https://orcid.org/0000-0002-1038-1885)
- Changjiang Wang (ORCID: https://orcid.org/0009-0003-2726-4049)
- Yingchun Sun
Institutions
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Yancheng First People's Hospital (CN)
- Yancheng Central Blood Station (CN)
- Yancheng Teachers University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s10020-025-01346-8
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67