Tumor sink effect on melanin-ligand [131I]ICF01012 in melanoma and its implications for targeted radionuclide therapy
These findings suggest that tumor burden impacts [<sup>131</sup>I]ICF01012 distribution in non-target organs, with potential clinical implications for dosimetry and toxicity mitigation in radiopharmaceutical therapy for metastatic melanoma. Further studies are needed to refine dosimetric models and assess the translational relevance of this effect in human subjects.
Authors
- Jacques Rouanet (ORCID: https://orcid.org/0000-0002-5821-0786)
- Philippe Auzeloux (ORCID: https://orcid.org/0000-0003-2066-3904)
- Sophie Besse (ORCID: https://orcid.org/0000-0002-9842-9002)
- Jean‐Michel Chezal (ORCID: https://orcid.org/0000-0001-7162-8450)
- Tommy Billoux (ORCID: https://orcid.org/0000-0003-3610-3709)
- Marine Delmas
- E. Jouberton (ORCID: https://orcid.org/0000-0002-0275-4055)
- Emmanuel Chautard
- Laurine Noirault
- N.C.F. van Sas
- M Auriol
- F. Cachin (ORCID: https://orcid.org/0000-0003-2171-1496)
- Sébastien Schmitt (ORCID: https://orcid.org/0000-0002-8468-6788)
- Benjamin Chaussin
- Elisabeth Miot-Noirault
- Sophie Lévesque
Institutions
- Inserm (FR)
- Université Clermont Auvergne (FR)
- Centre Jean Perrin (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Clermont Université (FR)
- Imagerie Moléculaire et Stratégies Théranostiques
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13550-025-01319-2
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Université Clermont-Auvergne
- Institute of Genetics