Carnitine deficiency augments methotrexate-mediated acute renal injury in rats
This research proposes that carnitine deficiency is a potential risk factor in the development of MTX-mediated AKI. MTX disrupts ACC1 signaling with the consequential inhibition of ATP production. Carnitine supplementation attenuates MTX-mediated AKI. Our results are preliminary and mandate further mechanistic study to justify the progression of AKI by MTX in CARN-deficient rats.
Authors
- Marwa Sharaky (ORCID: https://orcid.org/0000-0002-7894-3514)
- Mahmoud M. Khattab (ORCID: https://orcid.org/0000-0002-3217-5417)
- Riham M. Karkeet (ORCID: https://orcid.org/0000-0002-8779-8937)
- Mervat M. Omran (ORCID: https://orcid.org/0000-0003-1643-0104)
- Abdel‐Moneim M. Osman (ORCID: https://orcid.org/0000-0003-1668-450X)
- Mohamed M. Sayed‐Ahmed
- Fatema Alaa El-Din Selim
Institutions
- Cairo University (EG)
Publication Details
- Journal
- Journal of the Egyptian National Cancer Institute
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s43046-025-00321-y
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00