Hyaluronic acid–ornithine crosslinked hydrogel as a superior 3D culture platform for high-quality exosome production in advanced wound healing
This work presents a cost-effective, scalable, and bioinspired 3D culture system for high-yield and functionally enhanced Exo production. The HA-Orn hydrogel platform offers significant translational potential for advancing cell-free regenerative therapies, particularly in the context of wound healing.
Authors
- Shuangquan Qu (ORCID: https://orcid.org/0000-0002-3794-8845)
- Biwu Liu (ORCID: https://orcid.org/0000-0001-7357-9875)
- Jieru Yang (ORCID: https://orcid.org/0000-0002-2295-4812)
- Wenhu Zhou (ORCID: https://orcid.org/0000-0003-3794-661X)
- Pei Li
- Ke Li (ORCID: https://orcid.org/0000-0003-2671-926X)
- Yuan Tan (ORCID: https://orcid.org/0000-0003-2040-9359)
- Rui Zhao (ORCID: https://orcid.org/0000-0001-7191-9354)
Institutions
- Central South University (CN)
- Hunan Children's Hospital (CN)
- Sansure Biotech (China) (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13287-025-04635-5
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00