Human umbilical cord mesenchymal stem cells ameliorates cisplatin-induced blood-testis barrier dysfunction in mice by mitigating ferroptosis
hUC-MSCs protect against CDDP-induced reproductive injury by inhibiting ferroptosis (especially in Sertoli cells), repairing BTB, and restoring fertility. Their transient retention and low immunogenicity support their potential as a safe therapeutic strategy for preserving fertility in chemotherapy patients.
Authors
- Xuexia Liu (ORCID: https://orcid.org/0000-0002-1991-4473)
- Bin Gong (ORCID: https://orcid.org/0000-0002-9464-3423)
- Xueying Zhang (ORCID: https://orcid.org/0000-0001-5746-2191)
- Fujun Liu (ORCID: https://orcid.org/0000-0001-6708-207X)
- Peng Zhu (ORCID: https://orcid.org/0000-0002-3857-0282)
- Xi‐Lin Wang (ORCID: https://orcid.org/0000-0002-3990-6454)
- Yunhai Zhang (ORCID: https://orcid.org/0000-0001-9721-5910)
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Yuhuangding Hospital (CN)
- Bioscience (China) (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13287-025-04645-3
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shandong Province