Personalized transcriptional network analysis links age-related loss of gene coordination to individual biological aging
This study establishes, for the first time, a connection between the loss of gene-to-gene expression coordination and individual-level aging progress. It provides proof-of-principle evidence for using lost gene coordinated expression relationships as biomarkers of healthy aging and highlights the potential risks associated with coordination loss in specific biological pathways during aging.
Authors
- Fu‐Hui Xiao (ORCID: https://orcid.org/0000-0001-7478-7801)
- Long Zhao (ORCID: https://orcid.org/0000-0002-2700-1324)
- Tianrui Xia (ORCID: https://orcid.org/0009-0006-3335-8705)
- Haotian Wang (ORCID: https://orcid.org/0000-0002-0879-9123)
- Siyu Ma (ORCID: https://orcid.org/0000-0002-7717-6069)
- Qian Su
- Li-Qin Yang
Institutions
- Ningbo University (CN)
- Kunming Institute of Zoology (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s13073-025-01533-6
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences