RHBDD1 induces cell cycle arrest in TP53-mutant NSCLC cells by promoting endoplasmic reticulum-associated degradation of p53 and DNA-PKcs
RHBDD1 arrests the cell cycle in TP53-mutant NSCLC cells through ERAD-dependent downregulation of p53 and DNA-PKcs. However, cell survival may be enhanced due to the inhibition of DNA-PKcs-regulated apoptosis.
Authors
- Yang Wang (ORCID: https://orcid.org/0000-0001-9385-7393)
- Jun Liu (ORCID: https://orcid.org/0009-0009-8411-1931)
- Yun Chen (ORCID: https://orcid.org/0000-0002-2516-0946)
- Hao Peng (ORCID: https://orcid.org/0000-0002-6903-7325)
- Libin Zhang (ORCID: https://orcid.org/0009-0006-7620-3957)
- Xiangyun Yan (ORCID: https://orcid.org/0000-0002-9560-5760)
- Shali Shen (ORCID: https://orcid.org/0009-0007-4423-4262)
- Zheyuan Xu
Institutions
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s40001-025-03116-y
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kunming Medical University