Integrated multi-omics analysis reveals PTM networks as key regulators of colorectal cancer progression and immune evasion
This study establishes PTM networks as central regulators of CRC progression and immune resistance. The PTM-AS framework enables precision subtyping, while GALNT6 emerges as a novel therapeutic target for overcoming immunotherapy resistance.
Authors
- Minghao Yin (ORCID: https://orcid.org/0000-0002-6226-2394)
- Riliang Ma
- Changjun Lv (ORCID: https://orcid.org/0000-0002-7048-5264)
- Zhao Chen (ORCID: https://orcid.org/0000-0002-5782-3329)
- Ji Liu (ORCID: https://orcid.org/0000-0001-5024-129X)
- Yanyan Hu (ORCID: https://orcid.org/0000-0002-1698-5743)
- Linghui Pan (ORCID: https://orcid.org/0000-0003-1107-1261)
- Bing Yang (ORCID: https://orcid.org/0009-0003-7536-743X)
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Health Commission of Anhui Province (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1007/s12672-025-03445-8
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- National Natural Science Foundation of China