YULINK deficiency promotes cell death under glucose restriction in HCC cells in association with GLUT1-mediated glycolysis
Our results underscore the protective role of Yulink in HCC survival under glucose restriction and its pivotal function in glucose metabolism, suggesting a mechanistic link between lower Yulink expression and higher survival in patients with HCC.
Authors
- Yur‐Ren Kuo (ORCID: https://orcid.org/0000-0002-9388-5009)
- Ming‐Feng Hou (ORCID: https://orcid.org/0000-0001-6030-9702)
- Chung‐Sheng Lai (ORCID: https://orcid.org/0000-0002-1298-9325)
- Tsai‐Hsien Hung (ORCID: https://orcid.org/0000-0002-6173-0862)
- Alice L. Yu (ORCID: https://orcid.org/0000-0003-2444-0505)
- John Yu (ORCID: https://orcid.org/0000-0002-3237-4272)
- Yi‐Chia Wu (ORCID: https://orcid.org/0000-0002-1204-5973)
- Wei‐Ting Wang (ORCID: https://orcid.org/0000-0002-2064-9523)
- Yuh‐Jin Liang (ORCID: https://orcid.org/0000-0003-3774-3329)
- Ming-Wei Kuo
Institutions
- Chang Gung University of Science and Technology (TW)
- Kaohsiung Medical University (TW)
- University of San Diego (US)
- Chang Gung University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- University of California San Diego (US)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1186/s10020-025-01347-7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung Medical Foundation
- Ministry of Science and Technology, Taiwan
- Kaohsiung Medical University
- Chang Gung Memorial Hospital, Linkou
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- National Science and Technology Council