Integrating network pharmacology, molecular docking, and molecular dynamics simulations to explore potential compounds and mechanisms of <i>Coptis chinensis</i> in treating streptococcal infections

This study provides mechanistic insights into the multi-component, multi-target, and multi-pathway effects of <i>C. chinensis</i> against streptococcal infections. The findings offer a theoretical basis for future experimental validation and clinical translation.

Authors

Wenqiang Tang (ORCID: https://orcid.org/0000-0002-2972-5748)
Hongcai Ma
Zhuo Ma (ORCID: https://orcid.org/0000-0002-1080-0584)
Jiangyong Zeng (ORCID: https://orcid.org/0000-0002-9934-6786)
Wanxiang Qi
Bin Shi

Institutions

Tibet Academy of Agricultural and Animal Husbandry Sciences (CN)
Animal Husbandry and Veterinary Department (IN)
Research Institute of Animal Husbandry (MN)

Publication Details

Journal: PeerJ
Published: 2025-09-26
DOI: https://doi.org/10.7717/peerj.19960
Primary Topic: Natural product bioactivities and synthesis
Type: article
Field-Weighted Citation Impact: 0.00

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article

Integrating network pharmacology, molecular docking, and molecular dynamics simulations to explore potential compounds and mechanisms of Coptis chinensis in treating streptococcal infections

Wenqiang Tang, Hongcai Ma, Zhuo Ma, Jiangyong Zeng et al.

Sep 26, 2025

PeerJ

Natural product bioactivities and synthesis

article

Integrating network pharmacology, molecular docking, and molecular dynamics simulations to explore potential compounds and mechanisms of Coptis chinensis in treating streptococcal infections

Wenqiang Tang, Hongcai Ma, Zhuo Ma, Jiangyong Zeng, Wanxiang Qi, Bin Shi

September 26, 2025article en

Abstract

This study provides mechanistic insights into the multi-component, multi-target, and multi-pathway effects of <i>C. chinensis</i> against streptococcal infections. The findings offer a theoretical basis for future experimental validation and clinical translation.

PeerJVol. 13

Tibet Academy of Agricultural and Animal Husbandry Sciences (CN), Animal Husbandry and Veterinary Department (IN), Research Institute of Animal Husbandry (MN)

Openalex Percentile: Top 77%

Natural product bioactivities and synthesis

DOI Open Access PDF OpenAlex

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Integrating network pharmacology, molecular docking, and molecular dynamics simulations to explore potential compounds and mechanisms of <i>Coptis chinensis</i> in treating streptococcal infections — Wenqiang Tang, Hongcai Ma, et al. · PeerJ (2025) | TGRS Research Map | TGRS