Validating the Gender Variance Scale in Italian: Psychometric Properties and Associations with Health and Sociodemographic Factors

<b>Background:</b> The Gender Variance Scale (GVS) was developed to assess self-perceived masculinity and femininity across diverse gender identities, including binary and non-binary experiences. To date, no validated Italian version was available. <b>Methods:</b> A total of 356 participants (192 transgender and gender-diverse [TGD], 164 cisgender) completed the Italian GVS and the SF-12 Health Survey. Translation and cultural adaptation followed international guidelines. Psychometric evaluation included confirmatory factor analysis (CFA), internal consistency, test-retest reliability (<i>n</i> = 63), convergent validity with health-related quality of life, and group comparisons across gender identity categories. <b>Results:</b> CFA supported the original two-factor model (CFI = 0.916, TLI = 0.905, RMSEA = 0.076, SRMR = 0.053). Internal consistency was high (α = 0.89). The GVS distinguished between gender identity groups: TGD participants scored higher than cisgender peers, and non-binary individuals reported significantly lower scores than both binary groups. Test-retest reliability was strong (r = 0.87-0.99; ICC = 0.992-0.996). <b>Conclusions</b>: The Italian GVS is a valid and reliable measure of gender variance. It provides clinicians, researchers, and educators with a culturally appropriate tool to assess gender expression and support inclusive practices in both community and clinical contexts.