Pharmacokinetic-pharmacodynamic target attainment analyses as support for meropenem dosing regimens in critically ill adult and elderly patients with Pseudomonas aeruginosa infections

Age-related increases in meropenem distribution volume necessitate tailored dosing regimens in critically ill patients. More frequent administration (q6h) improved CFR, particularly in elderly populations. Model-informed precision dosing may enhance treatment success against P. aeruginosa infections in intensive care settings.