Untargeted metabolomics reveals distinct biomarkers and metabolic alterations in familial and non-genetic hypercholesterolemia in Saudi patients
This study demonstrates the utility of untargeted metabolomics in distinguishing FH from HC, identifying 17α-OHP and cholic acid as potential FH biomarkers, while uric acid and choline may serve as HC-specific metabolic markers. These findings provide new insights for personalized interventions, enhancing disease stratification and therapeutic decision-making between genetic and non-genetic hypercholesterolemia.
Authors
- Abdulrahman Mujalli (ORCID: https://orcid.org/0000-0002-8630-3963)
- Hadiah Bassam Al Mahdi (ORCID: https://orcid.org/0000-0003-3483-9499)
- Zuhier Awan (ORCID: https://orcid.org/0000-0002-4176-335X)
- Hussam Daghistani (ORCID: https://orcid.org/0000-0001-8491-8350)
- Reem Nabil Hassan (ORCID: https://orcid.org/0000-0002-4671-7053)
- Rawabi Zahed
- Sherif Edris (ORCID: https://orcid.org/0000-0002-2810-3736)
- Noor Ahmad Shaik (ORCID: https://orcid.org/0000-0002-7133-656X)
- Ahmad A. Obaid (ORCID: https://orcid.org/0000-0003-2678-4424)
- Kawthar Saad Alghamdi (ORCID: https://orcid.org/0000-0002-6734-7573)
- Babajan Banaganapalli
- Faisal Alandejani
Institutions
- King Abdulaziz University (SA)
- Umm al-Qura University (SA)
- University of Jeddah (SA)
- University of Hafr Al-Batin (SA)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fmed.2025.1670282
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00