Higher aged neutrophils and differential inflammatory profiles in sickle cell disease patients on chronic transfusion therapy versus those on hydroxyurea
Lower numbers of total and aged neutrophils and lower levels of several cytokines and chemokines in the HU group highlight the drug's potential to modulate leukocyte activation and recruitment. These findings suggest that adding or maintaining HU therapy in SCD patients undergoing CT could potentially enhance immunologic regulation and warrants further study.
Authors
- Deepa Manwani (ORCID: https://orcid.org/0000-0003-1057-1811)
- Jacob S. Kazmi (ORCID: https://orcid.org/0009-0000-3644-5894)
- Jennifer De Los Santos
- Janine Keenan
- Libusha Kelly (ORCID: https://orcid.org/0000-0002-7303-1022)
- Aakash Mahant Mahant (ORCID: https://orcid.org/0000-0002-0530-122X)
- Betsy C. Herold (ORCID: https://orcid.org/0000-0001-9974-0786)
- Anayeli Correa
- Paul S. Frenette (ORCID: https://orcid.org/0000-0003-0862-9922)
- Ilir Agalliu (ORCID: https://orcid.org/0000-0002-6248-5790)
- Zachary Flamholz (ORCID: https://orcid.org/0000-0002-0129-8836)
- Karen Ireland
- Katrina Terrigno
Institutions
- Albert Einstein College of Medicine (US)
- St. Jude Children's Research Hospital (US)
- Children's Hospital at Montefiore (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1671061
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute