Metabolic dysregulation in the heart in obesity-associated HFpEF
Distinct alterations in cardiac mitochondrial function were observed depending on the presence or absence of IR in obese HFpEF mice. These findings suggest that SIRT3 may play a central role in mediating mitochondrial adaptations in the heart and could represent a promising therapeutic target in HFpEF.
Authors
- Christine M. Kusminski
- Eng Leng Saw (ORCID: https://orcid.org/0000-0002-0845-191X)
- Flora Sam (ORCID: https://orcid.org/0000-0001-8442-9362)
- María Valero‐Muñoz (ORCID: https://orcid.org/0000-0002-1412-7366)
- Philipp E. Scherer (ORCID: https://orcid.org/0000-0003-0680-3392)
- Hannah Cooper (ORCID: https://orcid.org/0009-0001-3694-2230)
- Shanpeng Li (ORCID: https://orcid.org/0000-0002-0724-4564)
- Richard Wilson
Institutions
- Boston University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fcvm.2025.1678992
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health