Probiotic intervention improves cholestatic parameters in patients with drug-induced liver injury: a real-world retrospective study
Probiotic intervention significantly improved cholestasis-related parameters and reduced the severity of liver injury in patients with DILI. This real-world study provides novel clinical evidence supporting microbiota-targeted therapy as a promising adjunctive strategy, particularly for cholestasis-predominant DILI.
Authors
- Jiwu Guo (ORCID: https://orcid.org/0000-0002-7496-8300)
- Zhixiang Mou
- Jizhen Wang
- Na Li (ORCID: https://orcid.org/0000-0001-8779-631X)
- Penghui Liu (ORCID: https://orcid.org/0000-0003-4928-6874)
- Lingyun Guo (ORCID: https://orcid.org/0000-0003-0204-6961)
- Jie Mao (ORCID: https://orcid.org/0000-0003-4641-4674)
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fnut.2025.1657629
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00