Radiation‐induced extracellular vesicles from cancer‐associated fibroblasts drive oesophageal squamous cell carcinoma metastasis via the miR‐193a‐3p/PTEN/Akt pathway
The poor prognosis of oesophageal squamous cell carcinoma (ESCC) is largely driven by recurrence and metastasis following radiation therapy. Irradiated cancer-associated fibroblasts (CAFs) drive ESCC recurrence and metastasis through extracellular vesicles (EVs), highlighting their critical role in the post-radiation tumor microenvironment. CAF-derived EVs deliver miR-193a-3p to ESCC cells, suppressing PTEN and activating Akt signaling, thereby enhancing invasion, migration, epithelialmesenchymal transition (EMT), and metastatic potential. High plasma exosomal miR-193a-3p levels predict poor prognosis in ESCC patients and may guide therapeutic strategies after radiotherapy.
Authors
- Zhengfei Zhu (ORCID: https://orcid.org/0000-0001-7537-3619)
- Jianjiao Ni (ORCID: https://orcid.org/0000-0003-3113-2586)
- Xi Yang (ORCID: https://orcid.org/0000-0001-6125-7641)
- Shanshan Jiang (ORCID: https://orcid.org/0000-0003-3461-6076)
- Xiao Chu
- Yue Zhou (ORCID: https://orcid.org/0000-0001-7781-7228)
- Fangyu Chen (ORCID: https://orcid.org/0000-0002-4512-7190)
- Li Chu (ORCID: https://orcid.org/0000-0002-6301-2709)
- Yida Li (ORCID: https://orcid.org/0000-0002-4578-3489)
- Tiantian Guo (ORCID: https://orcid.org/0000-0001-6189-7526)
- Yechun Pang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1002/ctm2.70483
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Fudan University
- National Key Research and Development Program of China