Next-generation sequencing reveals clinical features and prognosis of gene mutations in Chinese children with T-cell acute lymphoblastic leukaemia
This study reported the gene mutation spectrum of Chinese paediatric T-ALL, highlighting the role of NGS in molecular classification, risk stratification, and prognosis. Additionally, we emphasised the role of the variant allele frequency of <i>NOTCH1</i> mutations in the treatment response and prognosis of childhood T-ALL.
Authors
- Senlin Zhang (ORCID: https://orcid.org/0000-0001-5117-3110)
- Xinran Chu
- Lijun Gao (ORCID: https://orcid.org/0000-0002-2304-102X)
- Shaoyan Hu (ORCID: https://orcid.org/0000-0003-1285-9499)
- Yixin Hu (ORCID: https://orcid.org/0000-0001-5771-2023)
- Shuiyan Wu (ORCID: https://orcid.org/0000-0002-8963-5082)
- Huihui Wan (ORCID: https://orcid.org/0000-0001-8642-731X)
- Ping Chen (ORCID: https://orcid.org/0000-0002-4549-1355)
- Bohan Li (ORCID: https://orcid.org/0000-0003-2952-146X)
- Ji Qi (ORCID: https://orcid.org/0000-0001-8791-0725)
- Hu Liu (ORCID: https://orcid.org/0000-0003-3840-8135)
- Xiao Zhang (ORCID: https://orcid.org/0000-0001-7842-9489)
- Yongping Zhang (ORCID: https://orcid.org/0000-0002-3681-7579)
- Yu Liu (ORCID: https://orcid.org/0000-0002-5100-244X)
- Zhiheng Li (ORCID: https://orcid.org/0000-0002-1523-1114)
- Yizhen Li (ORCID: https://orcid.org/0000-0001-8941-6691)
- Wei Gao (ORCID: https://orcid.org/0000-0002-5043-6692)
- Na Meng (ORCID: https://orcid.org/0000-0002-5234-8872)
- Yuanyuan Tian (ORCID: https://orcid.org/0000-0003-2918-7270)
Institutions
- Soochow University (TW)
- Soochow University (CN)
- Shanghai Children's Medical Center (CN)
- Suzhou Kowloon Hospital (CN)
- Key Laboratory of Guangdong Province (CN)
- Second Hospital of Shandong University (CN)
- Suzhou Research Institute (CN)
- Xinxiang Central Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fonc.2025.1666527
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Soochow University
- National Key Research and Development Program of China