Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study
Authors
- Michael Sean Wiesener (ORCID: https://orcid.org/0000-0003-4992-3132)
- Rubeen Israni
- Michihiro Hosojima (ORCID: https://orcid.org/0000-0002-2750-735X)
- Y.K. Onno Teng
- Ying Tan (ORCID: https://orcid.org/0000-0002-8139-5758)
- Saliha Yıldırım (ORCID: https://orcid.org/0000-0002-2693-1167)
- Hamza Sakhi (ORCID: https://orcid.org/0000-0003-4977-2661)
- A Ramos Espinosa
- Liz Lightstone (ORCID: https://orcid.org/0000-0002-4603-4076)
- Narayan Prasad (ORCID: https://orcid.org/0000-0001-9801-0474)
- Sosuke Fukui
- Hirofumi Watanabe (ORCID: https://orcid.org/0000-0003-2277-2784)
- Antonio Gargiulo (ORCID: https://orcid.org/0000-0002-7139-5412)
- Ute Eisenberger (ORCID: https://orcid.org/0000-0003-3862-6933)
- Hidemichi Kouzu (ORCID: https://orcid.org/0000-0001-7815-1464)
- Tadashi Otsuka (ORCID: https://orcid.org/0000-0002-0572-3764)
- Pietro A. Canetta (ORCID: https://orcid.org/0000-0003-1130-5486)
- Richard J. Smith (ORCID: https://orcid.org/0000-0003-1201-6731)
- Nicholas J.A. Webb (ORCID: https://orcid.org/0000-0001-8572-5446)
- Dong‐Yuan Chang
- Maddalena Marasà (ORCID: https://orcid.org/0000-0003-0712-2329)
- Andrew S. Bomback (ORCID: https://orcid.org/0000-0001-5449-1667)
- Edwin Wong (ORCID: https://orcid.org/0000-0003-4867-6117)
- Yoshikatsu Kaneko (ORCID: https://orcid.org/0000-0002-6396-0055)
- Özant Helvacı (ORCID: https://orcid.org/0000-0002-1382-2439)
- Malte A. Kluger (ORCID: https://orcid.org/0000-0001-8186-5679)
- M. Lynn Weir (ORCID: https://orcid.org/0000-0001-6736-603X)
- Laila‐Yasmin Mani (ORCID: https://orcid.org/0000-0002-4693-7814)
- Giuseppe Remuzzi (ORCID: https://orcid.org/0000-0002-6194-3446)
- Teresa Cavero (ORCID: https://orcid.org/0000-0001-5187-9906)
- Tomohisa Yamashita (ORCID: https://orcid.org/0000-0001-9808-7623)
- Wooin Ahn
- Benaya Rozen‐Zvi
- David Kavanagh (ORCID: https://orcid.org/0000-0003-4718-0072)
- Yang Li (ORCID: https://orcid.org/0000-0003-1634-2470)
- Francisco José de la Prada Álvarez
- Fabiola Alonso García
- Hideyuki Kabasawa (ORCID: https://orcid.org/0009-0005-2159-7971)
- Dinesh Khullar (ORCID: https://orcid.org/0000-0003-4276-2575)
- Eva Jančová
- Federica Zotta (ORCID: https://orcid.org/0000-0001-9513-9344)
- Naomi Ben-Dor
- Amantia Imeraj (ORCID: https://orcid.org/0000-0002-7096-3203)
- Ipsita Krishnan
- Soufian Meziyerh (ORCID: https://orcid.org/0000-0001-7694-8381)
- Hanneke Bouwsma
- Tom Cairns
- Carla Nester (ORCID: https://orcid.org/0000-0002-0629-7576)
- Ryohei Kaseda
- Sibylle Tschumi
- Aude Servais (ORCID: https://orcid.org/0000-0002-8165-8212)
- Elizabeth Hendren (ORCID: https://orcid.org/0000-0003-0905-4585)
- Jennifer G. Jetton (ORCID: https://orcid.org/0000-0003-0962-3880)
- Erica Daina (ORCID: https://orcid.org/0000-0002-2419-5493)
- Uyen Huynh‐Do (ORCID: https://orcid.org/0000-0002-7276-032X)
- Susan Huang
- Chuan‐Ming Hao (ORCID: https://orcid.org/0000-0002-4307-0987)
- Sophie Chauvet
- Nathalie Chavarot (ORCID: https://orcid.org/0000-0001-6361-1392)
- Benjamin Wilde (ORCID: https://orcid.org/0000-0002-5115-6799)
- Myriam Dao
- Motoki Matsuki
- Yael Borovitz (ORCID: https://orcid.org/0000-0001-6708-629X)
- Anne Dieterle
- Xin Zhang (ORCID: https://orcid.org/0000-0002-4064-6805)
- Matthias Meier (ORCID: https://orcid.org/0000-0001-9455-4538)
- Wouter T. Moest (ORCID: https://orcid.org/0000-0002-7442-5701)
- Rita Marcela Fortunato
- Nicholas Medjeral‐Thomas (ORCID: https://orcid.org/0000-0003-4593-9487)
- Daniel Landau (ORCID: https://orcid.org/0000-0001-6347-7891)
- Piero Ruggenenti (ORCID: https://orcid.org/0000-0002-8394-0879)
- Lingyun Lai (ORCID: https://orcid.org/0000-0002-0603-8750)
- Marina Vivarelli (ORCID: https://orcid.org/0000-0002-2448-1959)
- Dervla M. Connaughton (ORCID: https://orcid.org/0000-0003-3466-6305)
- Yasuhíro Suzuki (ORCID: https://orcid.org/0000-0002-1868-1938)
- Gianna Mastroianni Kirsztajn (ORCID: https://orcid.org/0000-0003-1317-4109)
- Angelo J. Trapani
- Julia Weinmann‐Menke (ORCID: https://orcid.org/0000-0001-7344-8381)
- Stephen P. McAdoo (ORCID: https://orcid.org/0000-0001-8260-8770)
- Faisal Rehman (ORCID: https://orcid.org/0000-0002-6804-3467)
- Roxane Gaïsset
- Christina J. Michels
- Masashi Mizuno (ORCID: https://orcid.org/0000-0002-6603-1446)
- Dennis A. J. van den Broek (ORCID: https://orcid.org/0000-0001-7135-4752)
- Charikleia Gakiopoulou
- Anja Gäckler (ORCID: https://orcid.org/0000-0002-3630-4386)
- Bixia Gao (ORCID: https://orcid.org/0000-0002-1836-0499)
- Juliana Mansur Siliano
- Marcello Chinali (ORCID: https://orcid.org/0000-0002-5813-9465)
- Tobias B. Huber (ORCID: https://orcid.org/0000-0001-7175-5062)
- Soumita Bagchi (ORCID: https://orcid.org/0000-0003-1562-9912)
- Asil Demirezen (ORCID: https://orcid.org/0009-0004-4449-8266)
- Wataru Ohwada (ORCID: https://orcid.org/0000-0002-8963-4071)
- Kostas Stylianou (ORCID: https://orcid.org/0000-0003-3678-9421)
- Arata Osanami
- Vladimı́r Tesař (ORCID: https://orcid.org/0000-0001-6982-0689)
- Betül Öğüt (ORCID: https://orcid.org/0000-0002-1385-7324)
- Ichiei Narita
- Imelda Schuhmann (ORCID: https://orcid.org/0009-0000-6056-6397)
- Toshiyuki Yano (ORCID: https://orcid.org/0000-0001-9655-3985)
- Jai Radhakrishnan (ORCID: https://orcid.org/0000-0003-3157-5141)
- Laila Almeida Viana (ORCID: https://orcid.org/0000-0002-7957-2196)
- Hangsoo Kim (ORCID: https://orcid.org/0009-0009-9248-3356)
- Dharmendra Bhadauria (ORCID: https://orcid.org/0000-0002-1273-8294)
- Matthew C. Pickering (ORCID: https://orcid.org/0000-0002-1153-0192)
- Luca Antonucci (ORCID: https://orcid.org/0000-0001-7662-079X)
- Nadia Viviana Fretes
- Pei Chen (ORCID: https://orcid.org/0000-0002-2017-576X)
- Shaojun Liu (ORCID: https://orcid.org/0000-0002-9201-9301)
- Yaqin Wang (ORCID: https://orcid.org/0000-0003-1927-5840)
- Xiaojuan Yu (ORCID: https://orcid.org/0000-0002-6017-7188)
- Suguru Yamamoto (ORCID: https://orcid.org/0000-0002-8279-2966)
- François Provôt (ORCID: https://orcid.org/0000-0003-0218-9153)
- Anne Blanchard (ORCID: https://orcid.org/0000-0002-0815-0586)
- Pablo Raffaele (ORCID: https://orcid.org/0000-0002-9726-4509)
- Aiko Popke Jan de Vries
- Allyson Medina
- Shin Goto (ORCID: https://orcid.org/0000-0002-6167-555X)
- Mercedes Salgueira Lazo
- Eleftheria‐Kleio Dermitzaki
- James A. Tumlin
- Ming Zhao
- Wenceslao Adrian Aguilera Morales
- Mari Mar Freijo
- Camillo Carrara
- Gerald B. Appel
- Katarina Benackova
- Mariela Navarro-Torress
- Pavel Roshanav
- Valeria Morduhovich
- Naoki Nagakawa
Institutions
- University of Iowa (US)
- Novartis (Switzerland) (CH)
- Mario Negri Institute for Pharmacological Research (IT)
- Peking University (CN)
- Columbia University Irving Medical Center (US)
- Royal Victoria Infirmary (GB)
- University of Iowa Stead Family Children’s Hospital (US)
- Novartis (United States) (US)
- Bambino Gesù Children's Hospital (IT)
- Peking University First Hospital (CN)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- The Lancet
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1016/s0140-6736(25)01148-1
- Citations
- 19
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 15.15
Funders
- Vanderbilt University
- Vanderbilt University Medical Center
- Novartis Pharma