In silico and in vitro analyses for the improved diagnosis of bacterial meningitis
<i>SodC, cfb, SP2020</i>, and <i>dmsA</i> have the potential to enhance the accuracy of molecular diagnostics for the four most common bacterial species causing meningitis. Moreover, a combined <i>in silico</i> and <i>in vitro</i> approach that leverages WGS deposited in databases such as PubMLST, offers an efficient and cost-effective means for the preliminary evaluation of diagnostic targets.
Authors
- Rosângela Assis Jacques (ORCID: https://orcid.org/0000-0002-6576-6045)
- Kanny Diallo (ORCID: https://orcid.org/0000-0002-0905-3980)
- Hansini Mandal
- Adeniyi Kolade Aderoba (ORCID: https://orcid.org/0000-0002-4333-9093)
- Vitalis Fambombi Feteh (ORCID: https://orcid.org/0000-0001-7072-7422)
- Odile B. Harrison (ORCID: https://orcid.org/0000-0002-1623-0295)
- Naima Nasir (ORCID: https://orcid.org/0000-0001-6817-9447)
- Keith A. Jolley (ORCID: https://orcid.org/0000-0002-0751-0287)
- James E. Bray (ORCID: https://orcid.org/0000-0003-3554-4254)
- Grace Wezi Mzumara (ORCID: https://orcid.org/0000-0001-8132-1620)
- Martin Maiden (ORCID: https://orcid.org/0000-0001-6321-5138)
- Jeremie Kolotioloman Tuo (ORCID: https://orcid.org/0000-0002-0904-6588)
- Simon T L Amoikon
Institutions
- University of Oxford (GB)
- Swiss Centre for Scientific Research (CI)
- Institut National Polytechnique Félix Houphouët-Boigny (CI)
- Institut National de Santé Publique (CI)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fmicb.2025.1655490
- Citations
- 2
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 2.37
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care