GAP-43 is associated with faster amyloid-associated neurodegeneration and cognitive decline in Alzheimer’s disease
Our findings provided evidence that CSF GAP-43 was related to the accelerated amyloid-associated neurodegeneration, and further contributed to cognitive decline. We also demonstrated that Aβ deposition may act as a trigger for synaptic dysfunction by promoting inflammation.
Authors
- Yaxin Li (ORCID: https://orcid.org/0000-0002-4271-8569)
- Lian Tang
- Xuanming Xu
Institutions
- Capital Medical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing Ditan Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fneur.2025.1629389
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00