Exosomal miRNA-148b/301a/423 cluster predicts pneumonitis risk in NSCLC with concurrent radiotherapy with immunotherapy via PTPN14-YAP signaling: a retrospective cohort study
RT-ICI therapy significantly increases pneumonitis risk in NSCLC, especially in autoimmune comorbidities. A serum exosomal miRNA cluster (miR-148b-3p/301a-3p/423-3p) enables early pneumonitis prediction and prognosis assessment, offering novel targets for prevention and monitoring.
Authors
- Baosen Zhou (ORCID: https://orcid.org/0000-0002-5311-3880)
- Chang Ji Zheng
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0001-7798-3816)
- Wenbo Zhao (ORCID: https://orcid.org/0009-0000-3327-003X)
- Jing Cao (ORCID: https://orcid.org/0000-0002-8759-6104)
Institutions
- Hebei University of Engineering (CN)
- Shenyang Fifth People Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1666946
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Medical University